Pulmonary Surface Activity in Induced Pulmonary Edema.
نویسندگان
چکیده
Induction of acute pulmonary edema in anesthetized dogs causes a large fall in compliance. out of proportion to lung volume (1), and a sharp increase in venous admixture that can be reversed by forcible inflation of the lungs (2). This pattern of abnormal function suggested alveolar closure (1, 2). Since alveolar stability depends in large measure on the presence of normal pulmonary surface properties (3), altered surface forces were consiclered as an underlying mechanism. Cook and co-workers (1) reasoned that the decrease in alv'eolar diameter, resulting from the accumulation of intra-alveolar fluid, would account for an increase in total surface forces. We examined the possibility that pulmonary edema alters alveolar surface tension properties, in this way contributing to alveolar instability and to the failure of respiratory function. It can 1)e shown that for alveoli, as for spherical surfaces, total surface forces equal twice the surface tension divided by the radius of curvature (4). We induced pulmonary edema in anesthetized dogs by rapid intravenous infusion of dextran. Surface activity of lung extracts was measured and correlated with morphologic changes. There was a regional loss or impairment of surface activity in the edematous lung, associated with areas
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Mathematical Modelling of Pulmonary Edema
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 44 شماره
صفحات -
تاریخ انتشار 1965